Heres a closer look at how it works: Reduce Hunger Signals to Help Control Cravings Semaglutide mimics GLP-1, a natural hormone that influences appetite centers in your brain
However, in prediabetes and diabetes, this signal is blunted by insulin resistance in the liver
Weight Loss Boost: These supplements are often formulated to support metabolic rate or energy levels, which can sometimes dip when you are in a significant calorie deficit
Fat loss with tirzepatide typically occurs gradually as the medication builds in the body and dosage increases over time
That slowdown is intentional and drives the satiety effect, but it also reduces bowel motility, producing constipation in roughly one quarter of users
If you couldn't tolerate GHK-CU, retinoids might work well, though they have their own adjustment period