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Keep reading Published on: February 23, 2026 Thomas A

Disclaimer This page is an educational research reference and is not medical advice

Key steps include leucine binding to the Sestrin2 protein, relieving its inhibition of the GATOR2 complex, subsequently promoting Rag GTPase complex activation, and ultimately recruiting mTORC1 to the lysosomal surface for activation by the Rheb protein ( Parallel pathological mechanisms beyond mTORC1