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In addition, emerging dual agonists combing the effects of GLP-1RAs with other peptides have shown a huge potential of superior effects on glycaemia and body weight in patients with T2D compared to currently available peptides

Semaglutide, a GLP-1RA, mitigates seizure severity and cognitive impairment through the inhibition of the lipopolysaccharide (LPS)- and nigericin-induced NLRP3 inflammasome pathway, reducing lactate dehydrogenase (LDH) release by microglial cells [53]

Int J Mol Sci 22:1527

Fu JM, Satterstrom FK, Peng M, Brand H, Collins RL, Dong S, et al

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