You should contact your GP or diabetes care team if: Cold sensitivity is severe, persistent, or progressively worsening You experience cold intolerance accompanied by other symptoms such as extreme fatigue, constipation, dry skin, hair loss, or unexplained weight gain You develop symptoms suggestive of hypothyroidism (underactive thyroid), which can cause cold sensitivity (note that while GLP-1 receptor agonists have been associated with C-cell tumours in rodent studies, there is no established link to hypothyroidism in humans) You notice signs of anaemia, such as pallor, breathlessness, or palpitations, which can cause cold sensitivity Cold hands or feet are accompanied by colour changes (white, blue, or red), pain, or numbness, which may indicate circulatory problems You experience unexplained fever, chills, or rigors, which could suggest infection You have symptoms of hypoglycaemia (low blood sugar) such as shakiness, sweating, or confusion, especially if you also take insulin or sulfonylureas NICE guidance (NG28) recommends regular monitoring of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, and tolerability
Clinical trials for semaglutide and tirzepatide showed rare but documented cases of acute pancreatitis, prompting FDA black-box warnings
Over time, that reduction may translate to steady weight loss, particularly when combined with sustainable lifestyle habits
In insulin-treated patients, disordered gastric emptying, even when not associated with gastrointestinal symptoms, can cause a mismatch between the onset of insulin action and the availability of absorbed carbohydrate, leading to suboptimal glycaemic control
Clinical studies show that chronic respiratory illnesses like asthma and chronic obstructive pulmonary disease (COPD) are associated with systemic and local elevation of neutrophils
It was posited that the antiviral and anti-inflammatory effects of N-acetylcysteine were mediated by the inhibition of the oxidative metabolic pathway including transcription factor NF-B and mitogen activated protein kinase p38
