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1 2 European Journal of Organic Chemistry

View source 03Sikiric P, Udovicic M, Barisic I, et al

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Mechanism Selective NNMT inhibition, proposed to preserve intracellular NAD+/SAM and reduce fat-cell lipogenesis demonstrated in mice, not humans

Dosage and Administration Lambs: 0.5mL at marking or weaning Sheep: 1 - 1.5mL pre-lambing Calves: 2 - 3mL from 2 months of age Cattle: 4 - 6mL pre-calving Dose by subcutaneous injection only

Key antibodies used included: anti-FOXO4 (two different clones, ab128908 and sc-373877), anti-StAR, anti-CYP11A1, anti-3-HSD, and anti-Ser15-phospho-p53