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At these higher concentrations, TMAO led to a small decrease in cell proliferation for all concentrations (Fig S1C-D)

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Science 287 , 12651269 (2000)

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34