Side effects observed in Phase 2 studies include nausea, vomiting, diarrhoea, decreased appetite, and injection-site reactions
More commonly, people quote the Lancet Diabetes & Endocrinology paper stating that the proportion of lean mass loss relative to total weight loss was similar to other obesity treatments, and that these findings could provide reassurance that a greater proportion of lean mass is not lost with retatrutide But other obesity treatments is vague
14.9% Average body weight lost by non-diabetic obese adults at 68 weeks STEP 1 Trial, NEJM 2021 People are taking various medications and opting for different treatments to lose weight
These coenzymes play key roles in glycolysis, pyruvate metabolism, protein and amino acid metabolism, pentose biosynthesis, glycerol metabolism, synthesis of high-energy phosphate bonds, and fatty acid metabolism
F., & STEP 1 Study Group (2021)
In contrast, white adipose tissues store excess fat and decrease energy expenditure