The dysbiosis of obesity can lead to increased gut permeability and allow proinflammatory molecules to enter systemic circulation
Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo
In certain instances, once drug exposure (e.g., concentration in the endolymph or perilymph) of a drug reaches steady state, the concentration of the drug in the endolymph or perilymph stays at or about the therapeutic dose for an extended period of time (e.g., one day, 2 days, 3 days, 4 days, 5 days, 6 days, 1 week, 2 weeks, 3 weeks, a month, two months, three months, six months, or one year)
When a patient is on drug A if drug B is added to drug A, there is an improvement in glycemic control
Once generic semaglutide becomes available, patients can expect significant cost savings
Fluid shifts: GLP-1 drugs can affect body fluid balance, potentially impacting optic nerve perfusion