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Prioritizing protein at every meal, using shakes or bars as supplements, and tracking intake carefully prevents the excessive lean mass loss that gives these medications a bad reputation for "making you skinny fat." Ignoring hydration Reduced food intake means reduced water intake from food sources

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Primary and secondary endpoints Primary endpoints of the present study were changes in % FMD, IMT, PAI-1, VCAM-1, MCP-1, BNP, hs-CRP, IL-6, TNF-, endothelin, E-selectin and resistin while the secondary endpoints were the changes in serum levels of adiponectin, leptin, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride