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TRPV1 is expressed in about 60% of vagal neurons, and TRPA1 in about 25%.[ref] In addition to chemical stimuli, TRP receptors respond to oxidative stress and systemic inflammation.[ref] Repeated activation and hyperexcitability: TRPA1 and TRPV1 receptors are often co-localized on the same cells

Patients with DKD who show clearly elevated urinary ferritin levels or increased exosomal ACSL4 expression may respond more strongly to the anti-ferroptotic effects of SGLT2 inhibitors and may gain greater renal benefit

The key is consistency and integration into your full metabolic plan

Biochim Biophys Acta 1724:108118 Herbette S, Roeckel-Drevet P, Drevet JR (2007) Seleno-independent glutathione peroxidases

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Erastin also binds directly to mitochondrial voltage-dependent anion channels