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437 PC4 has been shown to mediate transcriptional activation of several oncogenes

In particular, oxidative stress reduces the uptake of glutamate in astrocytes, a key step in the recycling of glutamate [16]

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And of course, we always recommend speaking with a professional

Ann Neurol 34:676681 Rodrigo R, Cauli O, Boix J, El Mlili N, Agusti A, Felipo V (2009) Role of NMDA receptors in acute liver failure and ammonia toxicity: therapeutical implications