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Why Systemic vs

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Collagen crosslinking is associated with cardiac remodeling in hypertrophic obstructive cardiomyopathy

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As a result of this process there is an overabundance of oxidants compared to anti-oxidants

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By targeting NNMT an enzyme elevated in adipose tissue it alters downstream metabolic signaling independent of hormonal pathways

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doi: 10.3390/medicina58020245 33 DanieleS.FrosiniD.PietrobonoD.PetrozziL.Lo GerfoA.BaldacciF.et al

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Research shows that men over 65 produce much less testosterone when stimulatedonly an 85% increase compared to 142% in younger men [2]

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