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Intracellular barriers to non-viral gene transfer

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Researchers believe this is due to increased ROS (increased oxidative stress) in the pancreatic beta cells.[ref] Related article : Type 2 Diabetes Genes Fatty liver disease: High homocysteine levels are associated with NAFLD (fatty liver disease, MAFLD)

Additionally, riboflavin stimulates the synthesis of normal extracellular matrix and decreases reactive oxygen species levels in keratoconus [438]

PloS Pathog (2011) 7(9):e1002197

This threshold will gradually widen over the coming years, and availability varies by region and GP surgery