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CARASIL (Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), caused by HTRA1 mutations, is considerably rarer and is associated with alopecia, spondylosis, and early-onset cognitive impairment

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For example, compositions as described herein may be reconstituted in, or may comprise, a liquid carrier (for example, water or juice), allowing for straightforward oral administration

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