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This way, the excess nitrogen is converted into urea, to be eliminated

The relevance of this enzyme is illustrated by the fact that global SOD2 deficiency leads to neonatal death in mice ( c plus cytochrome c oxidase system (Okado-Matsumoto and Fridovich, 2001)

2014 [cited 2021 Jul 16];37:394404

Its plasma concentration decreases with age: approximately 200 ng/ml at age 20 versus 80 ng/ml at age 60, correlating with the decline in regenerative capacity

Upon binding to AREs in the nucleus, NRF2 interacts with other co-activators, such as the CBP/p300 protein, forming a complex that further activates the transcription of antioxidant and detoxification genes [30]

Very long-term outcome of acute promyelocytic leukemia after treatment with all-trans retinoic acid and chemotherapy: the European APL Group experience