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Start your intake How GLP-1 Medications Affect Stomach Function GLP-1 receptor agonists like semaglutide and tirzepatide activate receptors on stomach muscle cells, which delays the rate at which the stomach contracts and pushes food into the small intestine

However, based on its pharmacokinetic profile, a minimum of 72 hours between doses is a reasonable guideline

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The standard tirzepatide dosing protocol starts at 2.5 mg weekly for the first four weeks, then increases in 2.5 mg increments every four weeks based on tolerability and response