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GLP-1RAs promote the polarization of macrophages toward the M2 phenotype, reshape the immune microenvironment and attenuate inflammation in RA Further GO enrichment analysis revealed that biological processes such as interleukin-6 production, IL-1 production, TNF- production, macrophage activation, and macrophage migration were enriched in the RA group compared to the RA + GLP-1RAs group (Fig