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GLP-1RAs and SGLT2is act through distinct and complementary mechanisms of action to exert glycemic control and cardiovascular benefits [4, 9]

In vitro human neutrophils activated by formyl-methonyl-leucyl-peptide were also attenuated by trimetazidine [151]

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H 2 O 2 is an efficient activator of the redox-regulated proinflammatory transcription factor NF-KB, where redox-regulation activates upstream kinases P13K and NIK leading to NF-KB translocation and promotor binding

Author contributions YZ: writingoriginal draft

[DOI] [PubMed] [Google Scholar] 54.Nersessian R.S.F., da Silva LM., Carvalho M.A.S., et al