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PE-22-28: PE-22-28 is a synthetic 7-amino acid peptide derived from spadin that selectively blocks TREK-1 two-pore domain potassium channels with an IC50 of 0.12 nM

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Motta, M., Seirio, M

Nat Prod Res 36(16):42384242 Murugesu S, Selamat J, Perumal V (2021) Phytochemistry, pharmacological properties, and recent applications of Ficus benghalensis and Ficus religiosa

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However, these medications have harmful and dangerous side effects