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This review will use the term MASLD, defined as the presence of hepatic steatosis with no other discernible cause, in conjunction with at least one cardiometabolic risk factor (CMRF), such as type 2 diabetes mellitus (T2DM), obesity, hypertension, or dyslipidemia

"But there will come a day when we no longer see these access barriers for GLP-1s."

L., Khalid, U., et al

Hence, a possible adipo-insular axis is reasonable, where the IGF system may play a significant role (43)

[DOI] [PMC free article] [PubMed] [Google Scholar] 54

The most recently approved type, tirzepatide [archived link], is called a dual agonist because it mimics the effects of two gut hormones, GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)