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In REDEFINE 1 , a 68-week, Phase 3a, multicenter, double-blind, placebo- and active-controlled trial, 3,417 adults with overweight or obesity but without diabetes were randomized to CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg), semaglutide 2.4 mg, cagrilintide 2.4 mg, or placebo
Recognized by WHO as the fifth leading global mortality risk factor, obesity serves as a primary pathogenic driver and exacerbating factor for multiple disorders, including cardiovascular diseases, diabetes mellitus, and specific malignancies
Single Hormone Focus: Semaglutide works mainly on the GLP-1 receptor