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The N-terminal thioredoxin domain is often described as two distinct motifs: an N-terminal motif (112) and a C-terminal motif (343) linked by helix 2 and which together form a four -sheet in the order 2134 with 3 anti-parallel to the others (Figure 5A)

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Azotaemia or proteinuria might be detectable before symptoms occur

See Additional file 1 for a description of the data normalization procedures and statistical analyses used to generate gene sets and/or ranked gene lists for each of the previously published gene-expression datasets