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It triggers a clean GH pulse without the hormonal noise, a finding documented in a peer-reviewed European Journal of Endocrinology study demonstrating that Ipamorelin stimulates growth hormone selectively without elevating ACTH, cortisol, or prolactin

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However, the 4-PL standard curves obtained in all the ELISA kits showed an R 2 value between 0.99 and 1 (Supplementary Figures S2, S3 and S4), and the results obtained showed the same range and sensitivity as those declared by the manufacturers (Supplementary Figures S2, S3 and S4)