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J Appl Polym Scince

During calorie restrictionespecially rapid weight lossthe body may break down muscle tissue for energy, which can slow metabolism and make long-term weight maintenance more difficult

In paired secretagogue models, concurrent GHRH and GHRP activation has been shown to produce synergistic growth hormone release, reflecting two functionally distinct pathways that converge at the level of pituitary output

D.CalderwoodD.GillespieA.CryanJ

This hyperactivation leads to profound nausea, uncontrollable vomiting, and acute dehydration within hours of exposure

Most patients continue treatment long-term for sustained weight loss