Combining both types of agents may yield additional benefits: in a recent observational propensity-matched study from 3 US claims databases of 12,854 patients with type 2 diabetes who added an SGLT2i or sulfonylurea to baseline GLP-1 RA treatment, adding an SGLT2i produced greater cardiovascular benefit (comprising MI, stroke, all-cause mortality, and HHF) [17]
(2006) 291:E46875
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Unlike semaglutide, tirzepatide works by activating two hormone receptors involved in appetite and metabolism: GLP-1 receptors GIP receptors This dual-action mechanism helps regulate hunger and improve metabolic function, which may result in greater weight loss for some patients
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The first ten days were uneventful aside from mild nausea around day three or four