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GLP-1 receptor agonists (RA), such as Ozempic and Mounjaro, were initially designed to help manage blood sugar in type 2 diabetes

It is evident that the substitution of an amino function for the hydroxyl group on C2 and the methylation of N10 are the primary structural differences between MTX and the structure of naturally occurring folic acid (Rubino 2001)

Bioconjugate Chemistry

Ann Rheum Dis (2014) 73(10):188897

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