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Some of the most common complaints include: Headache Swelling Rash Facial flushing Itchy skin Dizziness Numbness Diarrhea Vomiting High blood pressure Cold symptoms Anxiety Causes of Vitamin B12 Overdose Vitamin B12 is a water-soluble vitamin, which means that when we ingest too much of it, the excess amounts are flushed out of the body through urine