Because GHK-Cu is still being studied, its long-term effects are not fully known yet, so patch testing is always recommended before regular use
Notably, NRF2-inducing compounds, such as tBHQ and sulforaphane, modify distinct KEAP1 residues from oxidation by ROS, thus allowing for an additive effect in the presence of oxidative stress (Suzuki et al., 2019
[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Tepes M., Gojkovic S., Krezic I., Zizek H., Madzar Z., Santak G., Batelja L., Milavic M., Sikiric S., Kocman I., et al
[Google Scholar] Raja SB, Rajendiran V, Kasinathan NK, Amrithalakshmi P, Venkatabalasubramanian S, Murali MR, Devaraj H, Devaraj SN
10.1016/s0009-2797(01)00234-4 38 SilvaM
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