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"NTRK3 kinase fusions in Spitz tumours"

Inhibition of intestinal TPH1 in mice, through tissue-specific ablation or pharmacological inhibition, conveys protection from high-fat diet (HFD)-induced dyslipidaemia and glucose intolerance (38), however molecular mechanisms underlying this are not understood

Platelets 23 (8), 565570

the reduced distal sodium delivery is associated with relative activation of the RAAS, which together with the physiological post-feeding rising in insulin levels promote distal sodium reabsorption by activating the Na/K pump in the distal tubule (Fig

This makes them a dual-action therapy targeting both metabolic and inflammatory pathways

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