Of the plethora of articles retrieved from the second MEDLINE search, we identified 28 systematic reviews of animal stud-ies, [39-41] GSH-related genetic polymorphisms linked to various cancers (colorectal can-cer, [42] leukaemia, [43,44] lung cancer,[ 45,46] bladder cancer, [47] gastric cancer, [48,49] prostate cancer, [50-53] adult brain tumours, [54] basal cell carcinoma [55] ) and linked to other disorders (autism, [12, 13] hypertension, 56,57 respiratory diseases, [58,59] cataract, [60] myelodysplastic syndrome, [61,62] glioma [63] and male idio-pathic infertility.[ 64] ) There were 9 RCTs identified from two systematic reviews of the use of GSH to reduce chemotherapy-induced toxicity (6 cisplatin, 2 axaliplatin, 1 platinum)
[DOI] [PubMed] [Google Scholar] 212.Tong L
GPX4 normally inhibits ferroptosis by limiting lipid peroxides generated by ROS
The inability of antioxidant systems, such as GPX4-dependent pathways, to counteract ROS amplifies ferroptotic damage (90)
Enhance Recovery and Sleep Feeling rested and recovering quickly from physical activity are crucial for a high quality of life
It can regulate the production of MMPs, such as MMP-1 and MMP-3, by fibroblasts (31)