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In colorectal cancer, LPS binding to TLR4 similarly recruits and activates TRAF6, thereby stimulating the NF-B pathway, resulting in phosphorylation of p65/RelA and upregulation of VEGF-C expression, which in turn promotes lymphangiogenesis and lymphatic metastasis (123)

Li Y, Chen S, Li L, et al

This could support the findings that African-American men have a higher incidence of prostate cancer than white men (122)

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