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showed that liraglutide improved hepatic steatosis and inflammation and suggested that hepatic lipid accumulation was reduced through stimulating AMPK, which downregulates the mTOR complex 1 (mTORC1)/sterol regulatory element binding protein 1 (SREBP1) signaling pathway [16]

And importantly in our situation, it significantly suppresses muscle protein breakdown through multiple complex metabolic routes

Hufnagl C, Leisch M, Weiss L, Melchardt T, Moik M, Asslaber D, et al

Such a framework would not only validate the threshold effect identified herein but also clarify whether B12 supplementation in deficient women improves IVF outcomes and whether genetic factors modify this relationship

However, a 2025 study found that people who used weight-loss medication regained weight more rapidly, with an average monthly weight regain of 0.4kg compared with 0.1kg in those who followed behavioural weight management programmes

Injection site reactions : For injectable forms, including redness, itching, or mild swelling