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Obesity, like high blood pressure or diabetes, is a chronic condition that often requires long-term management rather than a short-term fix

Gastrointestinal Adverse Events Of the adverse effects reported during GLP-1 RA clinical trials, gastrointestinal symptoms were the most frequent, with nausea and diarrhea very common, and vomiting, constipation, abdominal pain, and dyspepsia considered to be relatively common [97]

These issues arise because the drug slows food movement through the digestive tract

Melatonin may potentiate this effect

"Impact of pH and Buffer Components on the Stability of Novel GLP-1/GIP Receptor Agonists." Molecular Pharmaceutics, 20(3), 1189-1201

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