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The body produces enzymes for multiple purposes, and blocking them entirely can create unintended consequences even when the primary effect (GLP-1 protection) is desirable

These findings support the observation, sometimes disputed, that inorganic sulfates are readily absorbed and excreted in urine, in spite of the osmotic effects that they can generate and which lead to their use as laxatives [11, 41]

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Kanekura K, Suzuki H, Aiso S, Matsuoka M (2009) ER stress and unfolded protein response in amyotrophic lateral sclerosis

There have even been a number of published case reports detailing how certain suspected cases of HELLP syndrome actually end up being extreme vitamin B12 deficiency rather than typical preeclampsia

(2020) 319:R6978