Grading/prognosis: use Child-Pugh and MELD-Na to describe severity and predict outcomes (decompensation, transplant priority)
This means that every time you think you are using 1mg of Tirzepatide, you are actually using 2mg
Activating both receptors can improve insulin secretion, enhance fat metabolism and amplify appetite suppression
10.1016/j.ejphar.2011.05.038 31 IlicS.DrmicD.ZarkovicK.KolencD.CoricM.BrcicL.et al (2010)
Niihara Y, Matsui NM, Shen YM, Akiyama DA, Johnson CS, Sunga MA, Magpayo J, Embury SH, Kalra VK, Cho SH, Tanaka KR (2005) L-glutamine therapy reduces endothelial adhesion of sickle red blood cells to human umbilical vein endothelial cells
The aging gut faces multiple challenges: Reduced bacterial diversity - fewer species means less metabolic flexibility Decreased butyrate producers - particularly Faecalibacterium prausnitzii and Roseburia species Slower transit time - affecting fermentation patterns Changes in digestive secretions - impacting bacterial growth conditions Medication effects - many common medications affect gut bacteria These changes create a cycle where reduced butyrate production may be linked with increased intestinal permeability, low-grade inflammation, and further microbiome changes
