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Recent human topical evidence A 2023 IRB-approved 21-woman topical trial of NEEL gel (a stabilized GHK-Cu topical) reported an average 28% increase in skin collagen density at 3 months, with a top quartile reporting 51%

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The greater concern is chronic accumulation over years of continuous use, which cycling protocols address by providing regular breaks

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Planning insight: if the first week is about getting through the body's reaction, the next several weeks are about protecting routine, judgment, and relapse resistance