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Depleting the dopamine level in PD will lead to overactivity of the indirect pathway and under activity of the direct pathway within the basal ganglia circuitry (41)

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Ketone-based metabolic therapy: is increased nad+ a primary mechanism

The cumulative load is called oxidative stress

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Pathophysiological processes where melatonin plays important roles Antiapoptotic activity Almost all the studies that monitored the melatonin-dependent antiapoptotic activities include disease models characterized by the presence of a hypoxicischemia (HI) event