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Some experience constipation or loose stools

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While Block founder Jack Dorsey cited productivity gains in AI as the reason for the layoffs, industry observers noted that Block effectively tripled its workforce from 2019 to 2025, from 3,800 workers to 12,000

It is best to start with low dosage first then eventually increase as needed

It notes older adults show higher constipation rates in GLP-1 trials, and that opioids and anticholinergics compound the slowing of motility

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