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Because berberine can lower blood sugar, taking it with a GLP-1 can lead to glucose levels that are too low, called hypoglycemia

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608 PKC inhibitor Ruboxistaurin: Ruboxistaurin targets the PKC- isoform implicated in diabetic microvascular complications

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Diabetes Res Clin Pract 150:167173 Ahern T et al (2013) Glucagon-like peptide-1 analogue therapy for psoriasis patients with obesity and type 2 diabetes: a prospective cohort study