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Second, the respective study populations were quite different, with STEP 1 including a younger, healthier population with more women (73.1% of the semaglutide arm in STEP 1 versus 27.7% in SELECT) and higher mean BMI (37.8 kg m 2 versus 33.3 kg m 2 , respectively) 14,21

Sermorelin is a synthetic version of naturally occurring growth hormone-releasing hormone (GHRH)

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Lack of long-term safety data: Most peptides have not been tested in large-scale human studies