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naltrexone-bupropion (Contrave), which requires blood pressure monitoring and is contraindicated in seizure disorders and uncontrolled hypertension

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The MHRA-approved indications specify appropriate patient selection criteria, and these medications should only be prescribed as part of a comprehensive weight management programme including dietary modification and increased physical activity

Insert the needle quickly at a 45-degree angle through the pinched tissue, avoiding a straight 90-degree approach which may penetrate too deeply into muscle