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Response: We acknowledge the commenter's concern regarding the measure's scientific acceptability, but note that the measure developer conducted pilot testing in 26 HOPDs across five states and demonstrated that the measure is both reliable and ( meaningful

However, the relative contribution of each pathway to overall efficacy in topical applications requires further clarification through mechanistic studies

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Detailed written instructions to demonstrate self injection technique

Good appetite suppression and only side effect was a headache the day after I took the shot

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