retrieved on: 2018-02-28
Image Credit: Love Employee / Shutterstock In a recent study published in the journal Nature Medicine , researchers compared major adverse cardiovascular events (MACE) between glucagon-like peptide-1 (GLP-1) receptor agonists and comparators, benchmarking real-world estimates against randomized trial data to guide clinical decision-making
Interestingly, T3 treatment had no effect on the GLP-1 levels in the culture medium of enteroendocrine STC-1 cells, NCI-H716 cells, and mouse intestinal organoids (Supplementary Fig
By helping people lose weight, medications such as GLP-1 receptor agonists may reduce the severity of sleep apnea and improve sleep quality
For patients who do not want or cannot tolerate an injection, Foundayo oral GLP-1 pill is a daily oral GLP-1 pill now available in the UAE
Men vs women dosing differences Men's typical dosing: Starting: 1mg Standard: 1.5mg (most common) Maximum: 2mg Sweet spot: Usually 1.5-2mg Higher doses = stronger effect but more nausea Women's typical dosing: Starting: 0.5mg Standard: 0.75-1mg (most common) Maximum: 1.5mg Sweet spot: Usually 0.75-1mg Women more sensitive (need less) Why women need less: Smaller average body weight Higher sensitivity to melanocortin activation Stronger side effects at equivalent doses Different hormonal environment FDA trials showed efficacy at lower doses Sex-specific considerations: Individual variation matters most: Sex-based guidelines are averages Some men respond to 1mg Some women need 1.5mg Track your personal response Adjusting dose based on response Signs dose is too low: Minimal or no effect on arousal No side effects either (might not have reached bloodstream?) Same as baseline sexuality Waited full 3 hours post-dose Tried 2-3 times with no response When to increase: Tolerated current dose well (minimal nausea ) Consistent lack of desired effects Increment by 0.5mg Try new dose 2-3 times before further adjusting Don't exceed maximum (2mg men, 1.5mg women) Signs dose is too high: Strong nausea (ruins experience) Vomiting (rare but possible) Flushing, feeling unwell Side effects outweigh benefits Effect is present but overshadowed When to decrease: Side effects too strong Reduce by 0.25-0.5mg Try lower dose 2-3 times Find balance between efficacy and tolerance Some prefer mild effect with no nausea vs strong effect with sickness Dose response curve: Long-term dosing patterns: Most settle on one dose after 3-5 trials Occasionally adjust based on circumstance Tolerance doesn't typically develop No need for cycling or breaks Can use as needed indefinitely Injection technique for PT-141 Proper subcutaneous administration
