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Footnotes Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations

None of them constitute clinical monitoring guidance they describe what research-community protocols typically track

These markers included increased plasma alanine and lactate levels and the presence of organic acids, such as 3-methyl-glutaconic and dicarboxylic acids, and Krebs cycle intermediates, in the urine of these patients [69]