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MTII is a valuable tool for the study of the agouti obesity syndrome and of the role of melanocortinergic neurons in feeding.
It is unlikely that the inclusion of these patients would substantially affect the generalizability of the findings
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Furthermore, despite clinical use for over 60 years as an anti-diabetic drug, the cellular mechanisms by which metformin exerts either its actions remain unclear
One supports cellular detoxification with indirect metabolic benefits
Finally, Gastrointestinal distress and dehydration may reduce natural anticoagulants like antithrombin III
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