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Unadjusted analysis found relatively higher (4 and 5.4% additional) weight loss, HbA1c (0.4% additional) reduction, and fewer gastrointestinal side effects with tirzepatide 10 and 15 mg, respectively, than with semaglutide 2.4 mg [25]

Also of a piece with this attitude is the right-to-try philosophy summed up by physician Gabrielle Lyon, whose fan base has a lot of overlap with the MAHA movement, on celebrity fitness trainer Jillian Michaels podcast last year while discussing peptides

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Starting body composition plays a major role, with individuals carrying higher body fat percentages often experiencing more dramatic absolute changes, while leaner individuals may see slower but steady improvements in stubborn fat areas