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Endocr Rev 35(1):59105
APOE4 has been found to negatively modify effects of iron on brain functionality before the manifestation of cognitive impairment (Kagerer et al., 2020), and can regulate iron-homeostatic proteins like ferritin to increase an individuals risk of conversion to AD (Ayton et al., Evidence for Ferroptosis in AD Iron Chelators A 2-year Phase II clinical trial reported desferrioxamine, an iron chelator, attenuates cognitive decline in AD (Crapper McLachlan et al., Deferiprone is an orally active, brain penetrant iron-chelator, approved for use in -thalassemia, currently, undergoing a Phase II clinical trial in mild cognitive impairment (MCI) and AD (Deferiprone to Delay Dementiaclinicaltrials.gov identifier: NCT03235686
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