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A poorly mixed peptide is either ineffective or potentially unsafe

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Enzyme-responsive drug delivery system has been demonstrated, which consist of triblock N-(2-hydroxypropyl methyl) acrylamide (HPMA) conjugated with tetrapeptide linker, which allows the high molecular weight (92 kDa) to degrade into low molecular weight (44 kDa) and deliver the paclitaxel drug at tumor site [54]