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When activated, AMPK promotes fat utilization, glucose uptake, improved energy production, and better metabolic efficiency

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The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)

P53, a transcription factor that can activate the inhibitor of the cell cycle and participate in DNA damage response and transcription of apoptosis [43], may also play a role in premature aging by causing reactive damage to DNA [44]

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The peptide is also reported to remain stable in human gastric juice for over 24 hours, which is unusual and theorized to underpin oral activity in animals