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EMBO Rep 6:497501 Pinheiro C, Chaves MM (2011) Photosynthesis and drought: can we make metabolic connections from available data

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The importance of this antioxidant pathway is illustrated in Nrf2 knockout mice in which lung neutrophil inflammation and pulmonary emphysema were evident as early as 8 weeks after cigarette smoke exposure, whereas wild-type mice showed no lung changes at 16 weeks